Sr. Scientist, Antibody/Fusion Protein Purification, Analytics, or Formulation

Ascent Services Group
Published
January 31, 2021
Location
Milpitas, CA
Category
Job Type

Description

Sr. Scientist, Antibody/Fusion Protein Purification, Analytics, or Formulation
Milpitas, CA

We are seeking a motivated and experienced Senior Scientist to work independently and lead a team contributing to Antibody/Fusion Protein Purification, Analytics, or Formulation.

Experience and Qualifications:

  • Ph.D. degree with at least 2 years of experience or Bachelor/Master's with more than 5 years of experience in therapeutic antibody/fusion protein research and development in a biopharmaceutical environment.
  • Working knowledge of cGMP environment, ensuring compliant documentation, and transferring the processes to contract manufacturing sites.
  • Ability to work effectively in a fast paced setting.
  • Excellent interpersonal and managing skills with the desire to work collaboratively and effectively in a team environment.
  • Strong communication skills including verbal, written, and scientific data presentation.
  • Strong background, proficient skills, and proven track record of successes inoneof the following areas:

Purification:

  • Proficient in protein/antibody purification using various chromatography techniques;
  • Demonstrated expertise in purification optimization to maximize cost-efficiency and yield;
  • Hands on experience in operating and maintaining AKTA chromatographic and Tangential Flow Filtration (TFF) systems;
  • Hands on experience in antibody/protein characterizations using various analytical techniques, such as gel analysis, spectrophotometer, HPLC, light scatting, mass spectrometer, Biacore/Fortebio.

Analytics/Formulation:

  • Strong background in antibody analytics and/or formulation development.
  • Extensive knowledge and hands-on experience in antibody analytic techniques, such as Mass Spec, HPLC, light scattering, CD, Biacore SPR, ITC, DSC, IEF, capillary isoelectric focusing, and/or other spectrophotometric methods.
  • Familiar with excipients, stabilizers, and additives to maintain the stability of antibodies.
  • Experience in managing or conducting stability programs, including real time, accelerated/forced degradation and freeze thaw studies.
  • Knowledge and experimental experience in antibody up/down stream process development would be considered a significant plus.
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