Research Scientist, Metabolomics

Stanford University
September 23, 2022
Palo Alto, CA
Job Type


Research Scientist, Metabolomics

**Dean of Research, Redwood City, California, United States**



Post Date 3 days ago

Requisition # 96241

* _This position is a three-year fixed-term appointment, with possibility of renewal based on programmatic need and funding availability, with a primary work site on Stanford University's main campus._

This will be fully on-site.

**School/Unit Description:** Stanford Sarafan ChEM-H is a new interdisciplinary institute focused on connectingChemistry,Engineering, andMedicine forHuman Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking products and services that promote healthy living, and to educate a new cadre of "physician-scientist-engineers" who will lead a rapidly evolving industry. The Sarafan ChEM-H Knowledge Centers connect researchers with talented staff scientists, tools, and techniques in medicinal chemistry, metabolomics, macromolecular structure, protein engineering, and high throughput screening.

**Position Summary:** The Sarafan ChEM-H Metabolomics Knowledge Center is seeking a highly motivated scientist to join our team supporting and collaborating on a wide range of metabolomics, lipidomics and drug discovery projects. The ideal candidate will have a strong analytical background in chromatography separation and mass spectrometry with focus on metabolomics, lipidomics and other small molecule applications. Your work portfolio will be diverse including but not limited to supporting research collaborations, LC/MS method development, performing routine LC/MS instruments maintenance, providing training and technical advice on the operation of LC/MS instruments and data analysis, providing general laboratory support and maintaining laboratory safety for the Metabolomics Knowledge Center shared research facility.

**Core duties:**

+ Support scientific and research collaborations in the areas of LC/MS applications for omics (i.e. metabolomics, lipidomics, etc.) and drug discovery.

+ Develop and optimize LC/MS based analytical methods for targeted and untargeted metabolomics and lipidomics analysis, peptide quantitation, metabolite ID and bioanalysis.

+ Conduct LC/MS experiments, data analysis and results interpretation.

+ Liaise between researchers, students, technical staff, scientists, vendors, and other university staff; serve as a resource, providing training and practical guidance. In particular, provide hands-on training and technical advice to postdoctoral fellows, predoctoral students, and research staffs on LC/MS instrumentation and analysis for metabolomics and lipidomics, etc. in the Metabolomics Knowledge Center.

+ Modify, repair, and troubleshoot complex equipment and experimental systems. In particular, perform routine LC/MS instrument maintenance, tuning and calibration.

+ Provide general lab support to ensure smooth operation of the shared LC/MS research facility, including managing chemical inventory, maintaining laboratory safety. Acquire and maintain tools, equipment, and chemicals associated with experimental or engineering projects.

+ Contribute to scientific discussions to support new analytical technology development and expansion.

+ Maintain documentation related to research studies and protocols, and perform administrative duties related to equipment and systems associated with research or engineering projects, as assigned. Contribute to publications and research proposals.

+ Provide guidance to technicians, operators, and others working in particular scientific or engineering function area.


**Education & Experience:**

Associate degree or certificate of completion in a related engineering or related scientific discipline, or three years of equivalent work experience or combination of education and relevant experience.

**Knowledge, Skills and Abilities:**

+ Expertise in mass spectrometry principles and applications for metabolomics and lipidomics, with key analytical and problem-solving skills, especially for QQQ, Q-TOF, ID-X MS systems.

+ Experience with data analysis, experimental process, and development of new LC/MS analytical solutions

+ Ability to write clear documentation, perform administrative duties, and research protocol maintenance related to research studies and/or scientific/engineering projects.

+ Hands-on experience in LC/MS small molecule applications, including method development, quantification, characterization, and structure elucidation.

+ Ability to interpret and determine validity of data and check own work.

+ Ability to interact, collaborate, and cooperate with colleagues in the highly interdisciplinary shared research environment of the Sarafan ChEM-H Knowledge Centers.

**Preferred qualifications and experience:**

+ Highly preferred: Ph.D. in analytical chemistry or related scientific discipline with 0-2 + years of industry or academic experience in metabolomics, lipidomics, or small molecule LC/MS application space, or MS/BS with 5+ years of solid LC/MS instrumentation and small molecule application experience.

+ Expertise in mass spectrometry principles and applications for metabolomics and lipidomics, with key analytical and problem-solving skills, especially for Agilent QQQ, Q-TOF, MSDiQ, and Themo ID-X MS systems.

+ Hands-on experience and troubleshooting skills on LC separation techniques (i.e. RP, HILIC)

+ Proficiency in performing untargeted and targeted metabolomics and lipidomics data processing, statistical analysis and data interpretation.

+ Hands-on experience in various biological sample preparation technique such as PP, LLE, and SPE.

+ General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.

+ Experience in various LC/MS data processing software such as Agilent MassHunter (i.e. Qual, Quant, Profinder, PCDL, Lipid Annotator, MPP), and Thermo Xcalibur, TraceFinder, Compound Discoverer, and Lipid Search etc.

+ Ability to collaborate, communicate and present results to researchers who have little knowledge of mass spectrometry, metabolomics and lipidomics workflow.

**Physical requirements*:**

+ Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

+ Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

+ Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.

+ Must have correctible vision to perform duties of the job.

+ Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.

+ Ability to lift heavy objects weighing up to 50 pounds.

+ Ability to work in a dusty, dirty, and odorous environment.

+ Position may require repetitive motion.

_* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job._

**Working conditions:**

+ May require working in close proximity to synthetic chemistry laboratory.

+ Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

+ Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

+ May require extended or unusual work hours based on research requirements and business needs.

**Why Stanford is for You**

Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:

+ **Freedom to grow.** We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.

+ **A caring culture.** We provide superb retirement plans, generous time-off, and family care resources.

+ **A healthier you.** Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.

+ **Discovery and fun.** Stroll through historic sculptures, trails, and museums.

+ **Enviable resources.** Enjoy free commuter programs, ridesharing incentives, discounts and more

The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.

Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

Additional Information

+ **Schedule: Full-time**

+ **Job Code: 4991**

+ **Employee Status: Fixed-Term**

+ **Grade: I**

+ **Requisition ID: 96241**

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